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KMID : 0388019950060010023
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Korean Journal Gynecologic Oncology and Colposcopy
1995 Volume.6 No. 1 p.23 ~ p.30
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The Detection of the p53 Protein in Cervical Cancer and CIN by Immunohistochemistry
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김홍곤
최기욱/홍기연/이희섭/민부기/김기석/문형배
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Abstract
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The cell cycle is composed of a series of steps which can be negatively or positively regulated by various factors.
p53 gene aberrations areocmmon in human malignancies, and recent studies suggest that in cervical carcinoma p53 function is inactivated either by comples formation with human papilloma virus (HPV) E6 product or by gene mutation.
To study the expression of p53 gene in the cervical cancer and cancer and cervical intraepithelial neoplasia, immunohistochemistry for the p53 protein was done in the 47 cases of squamous cell carcinoma, 6 cases of adenocarcinoma and 32 cases of
cervical intraepithelial neoplasia.
1. The p53 protein was detected in the 31% of cervical intraepithelial neoplasia (10/32) cases).
2. The p53 protein was detected in the 55% of invasive cervical cancer (29/53 cases).
3. By the histologic type of cervical cancer, the p53 protein was detected in the 57% of squamous cell carcinoma (27/47 cases) and 33% of(2/6 cases) adenocarcinoma.
The p53 protein was more frequently detected in the squamous cell carcinoma than in the adenocarcinoma.
4. By the staging in cervical cancer, the p53 protein was detected in the 31% of stage 0.50% of stage I a, 50% of stage I b, 75% of stage Ⅱa and 50% of stage Ⅱb.
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